What Is Hypochlorhydria?
Hypochlorhydria is the decreased production in the human body of the substance known chemically as hydrochloric acid. It is found inside the stomach in a controlled environment.
Hydrochloric acid – HCl according to its chemical symbols – fulfills a series of specific functions in the stomach. These functions are basically protection against external agents and digestion.
The stomach produces hydrochloric acid through specialized cells in the stomach. The acid-producing cells are stimulated by the substance histamine, which in turn is stimulated by the hormone gastrin. Conversely, when the acid is sufficient or excessive, the stomach itself signals the body to no longer stimulate itself with gastrin.
Under normal conditions, if the self-regulating system works, there will be no gastritis or hypochlorhydria. If the generation of hydrochloric acid falls well below the desired levels, then we do speak of hypochlorhydria, and even achlorhydria when no acid is generated.
Among the properties of hydrochloric acid in the stomach we have to:
- Denatures the proteins we eat in order to process them.
- Participates in the digestive process of carbohydrates.
- It destroys harmful microorganisms that could enter the body with food.
Although it may seem like a non-serious situation, hypochlorhydria has been associated with stomach cancer. Patients who have the disorder for a long time are more prone to this neoplasm.
Causes of hypochlorhydria
Over time, various causes of hypochlorhydria have been determined. Among them, the most important are:
- States of stress and anxiety: one of the most important causes of hypochlorhydria. Under stress, cells can stop producing hydrochloric acid.
- Aging: over the years our cells lose functions due to the deterioration of age. Among these lost functions is the correct hormonal secretion, and gastrin can be affected. Also the cells that produce hydrochloric acid age and slow down their metabolism. It is estimated that among those over sixty years there is a thirty percent prevalence of hypochlorhydria.
- Abusive use of antacids: people who suffer from recurrent gastritis run the risk of overusing drugs such as ranitidine or omeprazole. These drugs block acid production to relieve gastritis symptoms. However, although it is the desired effect, in excessive use they can lead to hypochlorhydria.
- Disorders of the pituitary: when this organ works incorrectly, the hormonal communication pathway between gastrin and histamine can be altered.
- Hypothyroidism: As a disease that affects many bodily functions, the low presence of thyroid hormones also affects the gastrin and histamine hormonal axis.
- Gastric surgeries: some procedures on the stomach that are invasive have the adverse effect of altering the production of hydrochloric acid. Especially surgeries where part of the organ is resected, subsequently lead to hypochlorhydria.